by Researchers at MIT have created an ingestible capsule that vibrates within the stomach, potentially offering a new approach to treating obesity. When the stomach is distended, it sends signals to the brain that induce a feeling of fullness. The vibrating capsule activates the stretch receptors in the stomach, creating an illusory sense of fullness. In animal studies, the capsule stimulated the release of hormones that signal satiety and reduced food intake by 40%. The researchers believe that if further research shows that the technology is safe for humans, this pill could provide a minimally invasive treatment for obesity.
The capsule, which is designed to be taken before meals, could be an alternative to current weight loss and appetite control methods. Dieters are often advised to drink a glass of water before eating to create a sense of fullness, as a full stomach and liquid in the stomach can send signals that suppress hunger. However, this vibrating capsule offers a more effective and targeted solution.
The capsule contains a vibrating element and is about the size of a multivitamin. It is powered by a small silver oxide battery and dissolves a gelatinous membrane in the stomach, activating the vibrating motor upon contact with gastric fluids. Once the pill starts vibrating, mechanoreceptors in the stomach are activated and send signals to the brain through the vagus nerve, stimulating the release of hormones that regulate food intake. In animal studies, the pill reduced food consumption by 40% and slowed weight gain.
The researchers believe that this pill could be a game-changer in the field of obesity treatment. It offers a non-invasive and minimally invasive alternative to current medical interventions like gastric bypass surgery or gastric balloons, which pose safety concerns. Many existing weight loss drugs also have to be injected and are not affordable for everyone. The vibrating capsule could be an affordable option for those who are unable to access expensive treatments.
The current version of the pill vibrates for about 30 minutes, but the researchers are exploring the possibility of prolonging the duration of vibration. They also plan to investigate wireless methods of turning the pill on and off as needed. The pill passed through the digestive tract within four to five days in animal studies, without causing any negative impacts.
The researchers aim to scale up the manufacturing of the capsules to enable clinical trials in humans. These trials would be crucial to determine the safety and effectiveness of the device, as well as the optimal timing and frequency of administration. The development of this vibrating capsule opens up new possibilities for the treatment of obesity, offering a cost-effective and easily accessible option for individuals worldwide.
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1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
